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GOAL Study

The urinary bladder has 2 principal functions, to adequately store urine and to efficiently empty urine. Coordination of these functions is accomplished through a complex interaction between peripheral innervations of the lower urinary tract and the micturition centres of the central nervous system. Overactive bladder is a syndrome characterised by bothersome lower urinary tract symptoms during the storage phase of bladder function which can result in urinary incontinence. If overactive bladder symptoms continue over a long period of time thickening of the bladder wall can result, which compounds the problem and makes it more difficult to treat.

Some research members at CKR are involved in a phase 3 international drug study funded by a pharmaceutical company to evaluate the safety and efficacy of a drug treatment regime for young people with uncontrolled overactive bladder symptoms. The multi centred, randomised, multi dose study is recruiting children aged between 12 – 17 years who have not been adequately managed with urotherapy, physiotherapy or anticholinergic therapy.

There are currently sixteen sites across thirteen countries involved in this study with a total of 31 participants recruited up to March 2016. The results will be very important for informing clinicians about appropriate pharmacological management of young people with this debilitating condition.